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The Week in Review: Whether this mechanism is sufficient to regenerate larger numbers of hub cells lost through damage is also unknown. To be maintained, stem cells must receive signals that prevent their differentiation and instruct them to self-renew. The pregnancy at the end functions as a prison to trap both Amy and the man she fled—the final surrender of inner boy and inner girl to a life sentence of husband and wife. Morphology and development of the testis niche Many stem cells, including those of the Drosophila testis, reside in stromal niches: Head to your video add-on section where you can start enjoying your new addition to your set-up. Consistent with this idea, in testes that are globally depleted of stat , GSCs show defects in adhesion and severe disruption of the hub-GSC interface before other signs of differentiation; even in GSCs that are still adjacent to the hub, E-cadherin is delocalized, centrosomes are misoriented and divisions are no longer oriented perpendicular to the hub.
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